首页> 外国专利> N- (5S, 6S, 9R) -5- amino-6- (2,3-difluorophenyl) -6,7,8,9-tetrahydro -5H- cyclohepta b pyridine-9-yl-4- ( 2-oxo-2,3-dihydro -1H- imidazo 4,5-b pyridin-1-yl) piperidine-1-carboxylate salt

N- (5S, 6S, 9R) -5- amino-6- (2,3-difluorophenyl) -6,7,8,9-tetrahydro -5H- cyclohepta b pyridine-9-yl-4- ( 2-oxo-2,3-dihydro -1H- imidazo 4,5-b pyridin-1-yl) piperidine-1-carboxylate salt

机译:N-(5S,6S,9R)-5-氨基-6-(2,3-二氟苯基)-6,7,8,9-四氢-5H-环庚[b]吡啶-9-基-4-(2 -oxo-2,3-dihydro -1H-咪唑并[4,5-b]吡啶-1-基)哌啶-1-甲酸盐

摘要

Disclosed is the hemisulfate of compound (I) and the crystalline form of the hemisulfate. Also disclosed are methods of using a hemisulfate of compound (I) as a CGRP receptor antagonist and a pharmaceutical composition comprising the hemisulfate of compound (I). Compound (I) hemisulfate is a migraine and other headache, neurogenic vasodilation, neurogenic inflammation, burns, circulatory shock, flushing associated with menopause, airway inflammatory diseases such as asthma, and chronic obstructive Useful for treating, preventing, or alleviating disorders including pulmonary disease (COPD).
机译:公开了化合物(I)的半硫酸盐和半硫酸盐的结晶形式。还公开了使用化合物(I)的半硫酸盐作为CGRP受体拮抗剂的方法和包含化合物(I)的半硫酸盐的药物组合物。化合物(I)的半硫酸盐是偏头痛和其他头痛,神经源性血管扩张,神经源性炎症,烧伤,循环性休克,与更年期有关的潮红,气道炎性疾病(如哮喘)和慢性阻塞性疾病,可用于治疗,预防或缓解疾病,包括肺部疾病(COPD)。

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