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Method of stabilizing a cryoprecipitate of plasma proteins for subjecting to virus inactivation heat treatment
Method of stabilizing a cryoprecipitate of plasma proteins for subjecting to virus inactivation heat treatment
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机译:稳定血浆蛋白冷沉淀以进行病毒灭活热处理的方法
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摘要
The invention relates to a method for obtaining cryoprecipitatable proteins, comprising a viral inactivation step by thermally treating a lyophilisate of these proteins, comprising, before rendering the proteins in the form of a lyophilisate, an initial addition step, to these proteins, of a stabilizing and solubilizing formulation containing a mixture consisting of arginine, at least one hydrophobic amino acid and of tribasic sodium citrate. The invention also relates to a concentrate consisting of at least one cryoprecipitable protein containing the stabilizing and solubilizing formulation introduced according to the method and being suited for therapeutic use.
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