METHOD FOR STABILIZING A CRYOPRECIPITATE OF PLASMATIC PROTEINS FOR BEING SUBJECTED TO A VIRAL INACTIVATION THERMAL TREATMENT

摘要

The invention relates to a process for obtaining cryoprecipitable proteins, comprising a step of viral inactivation by heat treatment of a lyophilizate of said proteins, comprising, before the introduction of the proteins in the form of lyophilisate, an initial step of adding, said proteins having a stabilizing and solubilizing formulation comprising a mixture of arginine, at least one hydrophobic amino acid and trisodium citrate. The invention also relates to a concentrate of at least one cryoprecipitable protein comprising the stabilizing and solubilizing formulation introduced according to the process and may be intended for therapeutic use.