Neuropilin fragments and neuropilin - crystal structure of an antibody complex

摘要

PROBLEM TO BE SOLVED: To provide an antibody which is bonded to neuropilin 1 (Nrp1) and/or neuropilin 2 (Nrp2), and a method for using the same.SOLUTION: In one aspect, an anti-panNrpantibody including a light chain variable domain sequence as shown in Fig.7 and/or a heavy chain variable domain sequence as shown in Fig.8, or a fragment thereof are/is provided. In another aspect, an anti-panNrpYW68.11 antibody Fab fragment including a sequence as shown in Fig.9A is provided. In still another aspect, an anti-panNrpYW68.11.26 antibody Fab fragment including a sequence as shown in Fig.9B is provided. In still another aspect, an anti-Nrp antibody competing with the anti-panNrpantibody with respect to a bonding of Nrp is provided.