Those which are disclosed are the amokishishirin formulation which includes minimum of 1 denaturation discharge components, minimum of 1 denaturation discharge components include minimum of 1 amokishishirin and the medicine reason approved carrier here. In a certain execution example, when being prescribed to the patient or the subject in feeding state, as for the amokishishirin formulation, (1) as for ratio of the part of AUC which from after the dosage 2 hour for the part of AUC which from dosage is measured after the dosage 2 hour is measured after the dosage 5 hour it is the lowest 2.0:1, the medicine movement profile for amokishishirin inside the blood plasma which is characterized with the notion that where ratio of the part of AUC which from after the dosage 5 hour for the part of AUC which in addition from dosage is measured after the dosage 2 hour is measured after the dosage 12 hour is the lowest 1.1:1, is presented. In further execution example, as for the amokishishirin formulation, 1) as for the percent which melts in 0.25 hours it is between 25 or 55 percent, 2) as for the percent which melts in 0.5 hours it is between 30 or 60 percent, 3) as for the percent which melts in 1 hours it is between 50 or 85 percent, 4) as for the percent which melts in 1.5 hours it is between 70 or 95 percent, average in vitro melting profile inside the decisive range which is characterized with the notion that where in addition 5) the percent which melts in 2 hours is minimum of 85 percent, is presented. In desirable execution example, the amokishishirin formulation presents these feature both parties.
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