In the treatment of depression and neuropathic pain (2R, 6R) - hydroxy-nor ketamine, (S) - dehydroepiandrosterone nor ketamine and other (R, S) - use of stereoisomers dehydro and hydroxylated metabolites of ketamine

摘要

The present disclosure provides pharmaceutical formulations containing (2R, 6R) -hydroxynorketamine, or (R)-or (S) -dehydronorketamine, or other stereoisomeric dehydro or hydroxylated ketamine metabolites. The present disclosure also provides novel ketamine metabolite prodrugs. The present disclosure is a method for the treatment of bipolar depression, major depressive disorder, neuropathic and chronic pain, such as complex regional pain syndrome (CRPS), and purified ketamine metabolism generation in patients in need of such treatment Or a ketamine metabolite prodrug is provided by direct administration.