Substituted benzyl amine compounds and medical, in particular their use in the treatment of hepatitis C virus (HCV) infection

摘要

The present invention provides a compound having the formula (I): or a salt, N-oxide or tautomer thereof, wherein A is CH, CF or nitrogen; E is CH, CF Or R0 is hydrogen or C1-2 alkyl; R1a is CONH2; CO2H; an optionally substituted acyclic C1-8 hydrocarbon group; and 3 to 7 ring members, Selected from optionally substituted monocyclic carbocyclic or heterocyclic groups wherein 0, 1, 2, 3 or 4 are heteroatom ring members selected from O, N and S R2 is selected from hydrogen and the group R2a; R2a is an optionally substituted acyclic d-8 hydrocarbon group; has 3 to 7 ring members, of which 0, 1 or 2 The ring member is a heteroatom ring member selected from O, N and S; An optionally substituted monocyclic carbocyclic or heterocyclic group; and an optionally substituted bicyclic ring having 9 or 10 members, one or two of which are nitrogen atoms Selected from the formula heterocyclic groups; at least one of R 1 and R 2 is other than hydrogen; R 3 is zero, one, two or three heteroatom ring members selected from N, O and S Including, optionally substituted, 3 to 10 membered monocyclic or bicyclic carbocyclic or heterocyclic ring; R4a is halogen; cyano; optionally substituted with one or more fluorine atoms C 1-4 alkyl; selected from C 1-4 alkoxy optionally substituted with one or more fluorine atoms; hydroxy-C 1-4 alkyl; and C 1-2 alkoxy-C 1-4 alkyl; R 5 is hydrogen and substituent From R5a R 5a is C 1-2 alkyl optionally substituted with one or more fluorine atoms; C 1-3 alkoxy optionally substituted with one or more fluorine atoms; halogen; cyclopropyl; cyano; Selected from amino. This compound has activity against hepatitis C virus and can be used for prevention or treatment of hepatitis C virus infection. [Selection figure] None