Tamper resistant oral pharmaceutical dosage forms comprising pharmacologically active ingredients, opioid antagonists and / or aversive agents, polyalkylene oxides and anionic polymers

摘要

The invention has a breaking strength of at least 300 N and (i) a pharmacologically active ingredient; (ii) an opioid antagonist and / or an aversive agent; (iii) an average molecular weight of at least 200,000 g / mol. And / or (b) an anionic polymer; and / or (b) a pharmaceutical agent for oral administration having a storage stability at 40 ° C. of at least 3 months Regarding the shape.