Stabilization and analysis of fatty acids in a biological sample stored on a solid medium

摘要

The present invention relates to chelating agents (eg, ethylenediaminetetraacetic acid, ascorbic acid, citric acid, or salts thereof) and antioxidants (eg, butylated hydroxytoluene, butylated) that can stabilize applied fatty acids. A solid medium (eg, paper, glass-based matrix, paper-based matrix, cellulosic matrix, hydrophilic polymer, polytetrafluoroethylene) containing hydroxyanisole or t-butylhydroquinone) and less than about 2 μg / cm 2 of contaminant. A method for stabilizing fatty acids present in samples such as body fluids (eg, blood, saliva, breast milk, urine, semen, plasma, and serum) using fiberglass, and porous ceramics, and And a method for making such a medium. The invention further relates to a method for determining the fatty acid composition of a sample stored on such a medium.