Hypoglycemic encephalopathy model and method for producing the same, screening method for neuroprotective agent, and neuroprotective agent

摘要

Glucose and a test substance are administered to a hypoglycemic encephalopathy model that is a non-human animal having a flat electroencephalogram and exhibiting at least one symptom selected from the group consisting of disappearance of light reflection, enlargement of pupils, and convulsions And a screening step of screening, as a neuroprotective agent, a test substance capable of suppressing at least one induction selected from the group consisting of generation of cytotoxic aldehydes in brain cells and neuronal degeneration A screening method for a protective agent; a hypoglycemic encephalopathy model used in the screening method, and a production method thereof.