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Micro RNA to control the identity of expression and muscle fiber of myosin
Micro RNA to control the identity of expression and muscle fiber of myosin
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机译:微小RNA控制肌球蛋白表达和肌纤维的身份
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摘要
The present invention relates to the identification of two microRNAs, miR-499 and miR-208b, that repress fast skeletal muscle contractile protein genes. Expression of miR-499 and/or miR-208b can be used to repress fast fiber genes and activate slow fiber genes in the treatment of musculoskeletal disorders. Inhibition of miR-499 and/or miR-208b is proposed as a treatment for cardiac hypertrophy, myocardial infarction, and/or heart failure. Pharmaceutical compositions comprising antagonists and agonists of miR-499 and miR-208b function are also disclosed.
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