FGF receptor activation N- sulfate oligosaccharides, the oligosaccharides of the preparation and the oligosaccharides of therapeutic applications

摘要

The invention relates to FGF receptor-activating N-sulfate oligosaccharides having Formula (I), wherein R1, R4, R6, and R8 are OSO3 or hydroxyl groups, R2 is an O-alkyl group or a monosaccharide having Formula (II), R3 is a disaccharide having Formula (III), R5 is a disaccharide having Formula (IV), R7 is a hydroxyl group or a disaccharide having Formula (VI), and R9 is a hydroxyl or O-alkyl group or a disaccharide having Formula (VII), where R10- is an O-alkyl group. The invention further relates to the preparation of said oligosaccharides and to the therapeutic use thereof.