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New anti-infective derivatives, processes for their preparation, use of the derivatives in pharmaceutical compositions containing them, and therapeutic
New anti-infective derivatives, processes for their preparation, use of the derivatives in pharmaceutical compositions containing them, and therapeutic
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机译:新的抗感染衍生物,其制备方法,该衍生物在含有它们的药物组合物中的用途以及治疗性
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摘要
The present invention relates to bi-substrate inhibitor molecules combining (i) a pyridine, pyridinium or dihydropyridine-type structure allied to active metabolites of isoniazide, or related structures, and (ii) a hydrophobic substituent. The invention also relates to the method for preparing said molecules, to the pharmaceutical compositions containing said molecules, and to the use thereof as inhibitors of enoyl reductase for the preparation of a drug, especially an anti-infective drug for the treatment of tuberculosis.
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