Methods and compositions for reducing risk associated with administration of opioid analgesics in patients with diagnosed respiratory disease or patients with undiagnosed respiratory disease

摘要

The present invention relates to methods for reducing the risk associated with the administration of opioid analgesics in patients diagnosed or undiagnosed with respiratory illness by administering an analgesic composition comprising a sub-analgesic dosage of a [mu]-opioid agonist selected from the group consisting of morphine, fentanyl, sufentanil, alfentanil, oxymorphone and hydromorphone, or a pharmaceutically acceptable salt thereof, and a sub-analgesic dosage of oxycodone which is a K2 -opioid agonist or a pharmaceutically acceptable salt thereof.