induction of pluripotent stem cell-like cells from the germ cells

摘要

There is provided a method of inducing an effective pluripotent stem cells from germ stem cells. The use of germ stem cells Sox2 and / or Oct4 is overexpressed, and may induce efficiently pluripotent stem cell-like cells as compared to the conventional method. The germ stem cells, Dnmt1 gene, or to suppress one or more genes selected from Dmap1 gene Dmrt1 gene and Oct1 gene or overexpression of Sox2 gene and / or Oct4 gene, or the Sox2 and / or Oct4 such as by introducing the protein directly. by the method according to can induce efficient pluripotent stem-like cells from the germ stem cells as compared to the conventional method.