Relates to a method for screening a compound having anti-estrogenic activity or estrogenic by the following steps invention, which comprises the steps of: providing the sample or cell line capable of expressing a single gene at least one of Table 1, the system step of incubation with the compound to be screened at least a portion of, and the step of comparing the gene expression in the cell lines of the control system in the expression of a single gene in Table 1. Another object of the present invention is directed to a method of monitoring by the following steps pathological conditions and / or physiologically elicited by estrogen receptor signaling, and is mediated, and are propagated / or: a single compound of at least one step of administering to a mammal in need of such treatment an effective amount, and determining the expression of a single gene in Table 1 in a biological sample collected from the mammal. The present invention, as well as substances that specifically interact with the gene product encoded by the genes of Table 1, also relates to the use of the genes of Table 1.
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