首页> 外国专利> TRPV1 MODULATORY GENE PRODUCT THAT AFFECTS TRPV1-SPECIFIC PAIN BEHAVIORAL RESPONSES IDENTIFIED IN A FUNCTIONAL SCREEN OF AN HSV-BASED cDNA LIBRARY

TRPV1 MODULATORY GENE PRODUCT THAT AFFECTS TRPV1-SPECIFIC PAIN BEHAVIORAL RESPONSES IDENTIFIED IN A FUNCTIONAL SCREEN OF AN HSV-BASED cDNA LIBRARY

机译：影响基于HSV的cDNA文库功能屏幕中识别的TRPV1特定疼痛行为的TRPV1调节基因产物

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摘要

The invention provides a method for ameliorating chronic pain signaling involving transient receptor potential cation channel subfamily V member 1 (TRPV1) by expressing PP1α in neurons. The invention also provides HSV vectors for expressing PP1α within neurons and compositions comprising such vectors.

机译：本发明提供了一种通过表达PP 1 α减轻涉及瞬时受体电位阳离子通道亚家族V成员 1 （TRPV 1 ）的慢性疼痛信号的方法。在神经元中。本发明还提供了用于在神经元内表达PP 1 α的HSV载体和包含这种载体的组合物。 展开▼

著录项

公开/公告号US2015297649A1

专利类型

公开/公告日2015-10-22

原文格式PDF

申请/专利权人 UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION;
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申请/专利号US201514690038

发明设计人 WILLIAM F. GOINS;JOSEPH C. GLORIOSO III;JUSTUS BERNHARD COHEN;BONNIE L. REINHART;
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申请日2015-04-17

分类号A61K35/763;C12N7;A61K9;C12N15/86;C12N9/16;

国家 US

入库时间 2022-08-21 15:27:18

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