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INTRANASAL INSULIN ADMINISTRATION FOR THE PREVENTION OF ANESTHESIA-INDUCED TAU PATHOLOGY/TAUOPATHIES
INTRANASAL INSULIN ADMINISTRATION FOR THE PREVENTION OF ANESTHESIA-INDUCED TAU PATHOLOGY/TAUOPATHIES
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机译:鼻内胰岛素管理以预防麻醉引起的TAU病理学/ TAUOPATHIES
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摘要
Intranasal administration of insulin for a predetermined period prior to anesthesia significantly prevented anesthesia-induced tau hyperphosphorylation and cognitive impairment and enhanced brain insulin signaling in mice. Intranasal insulin thus provides a treatment for prevention of anesthesia-induced tau pathology and increased risk for tauopathies in surgical patients and may be administered to a subject prior to anesthesia, such as by administering several doses of intranasal insulin for several consecutive days prior to any anesthesia.
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