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Na+/K+-ATPase-Specific Peptide Inhibitors/Activators of Src and Src Family Kinases
Na+/K+-ATPase-Specific Peptide Inhibitors/Activators of Src and Src Family Kinases
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机译：Na + / K + -ATPase特异性Src和Src家族激酶的肽抑制剂/激活剂
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摘要
A method for regulating Src and its downstream signaling pathway which includes binding between Src and Na+/K+-ATPase is disclosed. The Na+/K+-ATPase/Src complex is a functional receptor for cardiotonic steroids such as ouabain. Also disclosed are Src inhibitors or activators which include either Na+/K+-ATPase or Src that interfere with the interaction between the Na/K-ATPase and Src, act via a different mechanism from ATP analogues, and is pathway (Na+/K+-ATPase) specific.
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机译：公开了一种调节Src及其下游信号传导途径的方法，该方法包括Src与Na + / K + -ATP酶之间的结合。 Na + / K + -ATPase / Src复合物是强心类固醇（如哇巴因）的功能性受体。还公开了Src抑制剂或活化剂，包括Na + / K + -ATPase或Src，它们干扰Na / K-ATPase和Src之间的相互作用，通过与ATP类似物不同的机制起作用，并且是途径（Na + / K + -ATPase ）具体。
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