HIGH-THROUGHPUT ASSAYS FOR HIV-1 ENVELOPE MATURATION AND NOVEL PEPTIDE INHIBITORS AGAINST HIV-1

摘要

The invention provides peptide inhibitors against human immunodeficiency virus (HIV), including HIV-1, and compositions, formulations, and pharmaceutical compositions comprising same, and methods of making and using them. The invention provides methods for treating, ameliorating, slowing the progress of, reversing, or preventing a retroviral infection, an HIV infection, or an HIV-1 infection, or AIDS. In alternative embodiments, the invention provides compositions, including pharmaceutical compositions and formulations, comprising peptides or polypeptide having a sequence as set forth in SEQ ID NO:1 and/or SEQ ID NO:2, and peptidomimetics and bioisosteres thereof. In alternative embodiments, the invention provides cell-based platforms, multiplexed systems or platforms, or cell-based methods, for monitoring the activity of an HIV-1 protease (PR) enzyme, or for screening for a substrate of the HIV-1 protease (PR) enzyme.