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Method of rapidly inducing large-scale and high-purity mesenchymal stem cells to transdetermine into hematopoietic stem cells

机译:快速诱导大规模和高纯度的间充质干细胞转导为造血干细胞的方法

摘要

A method of rapidly inducing large-scale and high-purity mesenchymal stem cells to transdetermine into hematopoietic stem cells is provided with the steps of preparing homogeneous medium of mesenchymal stem cells; combining a plurality of small RNA molecules; assembling and transfecting nanoparticles of nucleic acids and polypeptides; inducing and amplifying medium of post-transdetermined hematopoietic stem cells; and activating a plurality of hemopoiesis-related genes.
机译:本发明提供了一种快速诱导大规模高纯度间充质干细胞转化为造血干细胞的方法,包括制备间充质干细胞均质培养基的步骤。结合多个小RNA分子;组装和转染核酸和多肽的纳米颗粒;转化后的造血干细胞的诱导和扩增培养基;并激活多个与造血相关的基因。

著录项

  • 公开/公告号US2015315545A1

    专利类型

  • 公开/公告日2015-11-05

    原文格式PDF

  • 申请/专利权人 BEIJING GINKGO BIOSCIENCE CO. LTD.;

    申请/专利号US201314343390

  • 发明设计人 QINWEI YIN;

    申请日2013-03-04

  • 分类号C12N5/0789;

  • 国家 US

  • 入库时间 2022-08-21 15:25:10

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