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METHODS FOR DELINEATING CELLULAR REGIONS AND CLASSIFYING REGIONS OF HISTOPATHOLOGY AND MICROANATOMY

机译:组织学和微解剖学的细胞区域的划定和分类的方法

摘要

Embodiments disclosed herein provide methods and systems for delineating cell nuclei and classifying regions of histopathology or microanatomy while remaining invariant to batch effects. These systems and methods can include providing a plurality of reference images of histology sections. A first set of basis functions can then be determined from the reference images. Then, the histopathology or microanatomy of the histology sections can be classified by reference to the first set of basis functions, or reference to human engineered features. A second set of basis functions can then be calculated for delineating cell nuclei from the reference images and delineating the nuclear regions of the histology sections based on the second set of basis functions.
机译:本文公开的实施方案提供了用于描绘细胞核并分类组织病理学或显微解剖学的区域同时保持批次效应不变的方法和系统。这些系统和方法可以包括提供组织学切片的多个参考图像。然后可以从参考图像确定第一组基础函数。然后,可以通过参考第一组基本函数或参考人类工程特征来对组织学部分的组织病理学或显微解剖进行分类。然后可以计算第二组基本函数,用于基于第二组基本函数从参考图像描绘细胞核并描绘组织学切片的核区域。

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