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Methods of Screening for Activation Deaminase Inhibitors Through Nuclear Import Inhibitors
Methods of Screening for Activation Deaminase Inhibitors Through Nuclear Import Inhibitors
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机译:通过核输入抑制剂筛选活化脱氨酶抑制剂的方法
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摘要
The present invention provides methods for obtaining specific and non-toxic inhibitors of AID nuclear import. The methods comprise a primary screen and a counter screen to identify a pool of AID specific nuclear import inhibitors that do not have off-target of toxic effects. AID specific nuclear import inhibitors identified by the screens of the invention prevent nuclear entry, limit the access of AID to genomic DNA, and inhibit AID mutagenic activity. Preparations, including pharmaceutical preparations, comprising specific nuclear import inhibitors, used for example, to inhibit cancer progression, are also encompassed in the invention.
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