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Preparation of Technetium-99M Tricarbonyl Labeled Glycine Monomer or Oligomer Containing Probes That Have Biomolecules and Its Application as Imaging Complex-Composition
Preparation of Technetium-99M Tricarbonyl Labeled Glycine Monomer or Oligomer Containing Probes That Have Biomolecules and Its Application as Imaging Complex-Composition
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机译:含生物分子探针的Tech 99M三羰基标记的甘氨酸单体或低聚物的制备及其作为成像复合物的应用
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摘要
Disclosed is a technetium-99m-labeled glycine oligomer associated with imaging probes for biomolecules of interest. The glycine oligomer can be readily synthesized in a single process using an automated peptide synthesizer. The technetium-99m tricarbonyl-labeled glycine oligomers can be useful as a radiotracer for gamma or SPECT imaging apparatus. The technetium-99m tricarbonyl-labeled glycine oligomers can be applied to various peptidyl biomolecules such as RGD peptide, somatostatin, neurotensin, etc., and exhibit rapid renal clearance without being excessively retained within the body.
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机译:公开了与感兴趣的生物分子的成像探针相关的a 99m标记的甘氨酸低聚物。甘氨酸低聚物可以使用自动化肽合成仪在单个过程中容易地合成。 m 99m三羰基标记的甘氨酸低聚物可用作伽马或SPECT成像设备的放射性示踪剂。 m 99m三羰基标记的甘氨酸低聚物可应用于各种肽基生物分子,例如RGD肽,生长抑素,神经降压素等,并显示出快速的肾脏清除率,而不会在体内过度保留。
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