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Inhibitors of the Epidermal Growth Factor Receptor- Heat Shock Protein 90 Binding Interaction
Inhibitors of the Epidermal Growth Factor Receptor- Heat Shock Protein 90 Binding Interaction
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机译:表皮生长因子受体-热激蛋白90结合相互作用的抑制剂
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摘要
Provided herein are compounds that inhibit a binding interaction between an epidermal growth factor receptor (EGFR) and a heat shock protein 90 (HSP90), as well as compositions, e.g., pharmaceutical compositions, comprising the same, and related kits. In some embodiments, the compound is an antibody or antibody analog, and, in other embodiments, the compound is a peptide or peptide analog. Also provided are methods of using the compounds, including methods of increasing degradation of an EGFR, methods of treating cancer, and methods of sensitizing tumors to radiation therapy.
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