COMPOSITIONS AND METHODS FOR INIHIBITING TUMORIGENICITY OF SENESCENT CANCER CELLS INDUCED BY CHEMOTHERAPY

摘要

The invention relates to the field of oncology and to chemotherapy resistance and relapse. Thus the invention provides compositions and methods for inhibiting tumorigenicity of senescent cancer cells induced by a chemotherapeutic agent. The invention also provides compositions and methods for inhibiting conversion of non-stem cancer cells (non-CSCs) into tumor initiating cancer stem cells (CSCs) induced by a chemotherapeutic agent.