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MULTI-FUNCTIONAL NUCLEIC ACID-BASED ANTI-CANCER DRUG CAPABLE OF TARGETING AND THERAPY, METHOD FOR PREPARING SAME AND ANTI-CANCER COMPOSITION COMPRISING SAME
MULTI-FUNCTIONAL NUCLEIC ACID-BASED ANTI-CANCER DRUG CAPABLE OF TARGETING AND THERAPY, METHOD FOR PREPARING SAME AND ANTI-CANCER COMPOSITION COMPRISING SAME
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机译:具有靶向和治疗作用的基于多功能核酸的抗癌药物,其制备方法和包含其的抗癌组合物
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摘要
The present invention relates to a multi-functional nucleic acid-based anti-cancer drug in which the anti-cancer drug is physically bound to a linear nucleic acid having a thiol group at 5′ terminal thereof and then gold nanoparticles and aptamers are chemically bound. The present invention also relates to a method for preparing the anti-cancer drug and to an anti-cancer composition comprising the anti-cancer drug. The multi-functional nucleic acid-based anti-cancer drug according to the present invention uses A10 aptamer to achieve high targeting properties, and uses high-concentration anti-cancer drugs and gold nanoparticles to enable dual therapy of thermal therapy/chemical therapy, and may have less side effects and be more effective in anti-cancer therapy compared to existing anti-cancer drugs.
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