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Magnetic resonance imaging and spectroscopy of low concentration solutes with exchangeable protons using label transfer modules: frequency transfer, inversion transfer, and dephasing transfer
Magnetic resonance imaging and spectroscopy of low concentration solutes with exchangeable protons using label transfer modules: frequency transfer, inversion transfer, and dephasing transfer
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机译:使用标签转移模块的具有可交换质子的低浓度溶质的磁共振成像和光谱:频率转移,反相转移和相移转移
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摘要
An embodiment of the current invention provides a method for magnetic resonance (MR) imaging or spectroscopy, comprising: (a) selectively exciting exchangeable solute protons or protons of exchangeable solute-based water molecules within a frequency range in a subject using at least one frequency-selective radio frequency (RF) pulse, wherein the frequency range encompasses characteristic resonance frequencies of the exchangeable solute protons or protons of exchangeable solute-based water molecules, wherein the frequency range is substantially non-overlapping with a characteristic resonance frequency of bulk water protons in the subject, wherein the at least one frequency selective RF pulse performs a substantially minimal excitation on the bulk water protons, and wherein the at least one frequency-selective RF pulse, sometimes in combination with a time period that separates the at least one frequency-selective RF pulse, magnetically labels the exchangeable solute protons or the exchangeable solute-based water molecules; (b) allowing a portion of the magnetically labeled exchangeable solute protons to exchange with the bulk water protons or allowing the magnetically labeled exchangeable solute-based water molecules to exchange with bulk water molecules;;(c) repeating (a) and (b) a plurality of times to enhance a population size of the magnetically labeled exchangeable solute protons or the magnetically labeled exchangeable solute-based water molecules; (d) irradiating the subject under observation with a water excitation RF pulse that is adapted to excite the bulk water protons; (e) recording a magnetic resonance (MR) signal from the subject under observation in response to the water excitation RF pulse; and (f) analyzing the recorded MR signal to estimate a quantity associated with the exchangeable solute protons or the exchangeable solute-based water molecules.
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