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G-protein coupled receptor-associated sorting protein 1 as a cancer biomarker
G-protein coupled receptor-associated sorting protein 1 as a cancer biomarker
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机译:G蛋白偶联受体相关分选蛋白1作为癌症生物标志物
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摘要
A method for determining whether early stage cancer is present in a subject comprises detecting the expression level of GASP-1 in the subject by detecting the amount of GASP-1 peptide fragments present in a biological sample of the subject. Because cancer can be detected at an early stage, therapeutic targeting may be initiated before cancer reaches late stage (e.g., before the development of overt symptoms). A method for treating early stage cancer in a subject comprises administering to the subject an effective amount of a GASP-1 inhibitor to inhibit the progression of early stage cancer to late stage cancer. A Competitive ELISA capable of detecting GASP-1 peptide fragments at a concentration of less than 1 ng/ml was developed.
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机译:用于确定受试者中是否存在早期癌症的方法包括通过检测受试者的生物样品中存在的GASP-1肽片段的量来检测受试者中GASP-1的表达水平。由于可以在早期发现癌症,因此可以在癌症达到晚期之前(例如,在出现明显症状之前)启动治疗靶向。一种用于治疗受试者的早期癌症的方法,包括向受试者施用有效量的GASP-1抑制剂,以抑制早期癌症向晚期癌症的发展。开发了一种能够检测浓度小于1 ng / ml的GASP-1肽片段的竞争性ELISA。
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