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Methods and compositions for production of recombinant protein in HBX-expressing mammalian cells
Methods and compositions for production of recombinant protein in HBX-expressing mammalian cells
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机译:在表达HBX的哺乳动物细胞中生产重组蛋白的方法和组合物
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摘要
The method of the invention provides for producing a heterologous protein in mammalian host cells having nucleic acid encoding Hepatitis B X protein and the heterologous protein, by growing mammalian host cells selected from the group consisting of HKB11, CHO, BHK21, C2C12, and HEK293 cells, by growing mammalian host cells in non-adherent suspension culture, or by growing mammalian host cells which contain nucleic acid providing exogenous X-box Binding Protein, XBP1s. The conditions should be such that HBx, exogenous XBP1s if present, and the heterologous protein are expressed by the mammalian cells. The invention includes compositions for carrying out the method.
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