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Yeast strain and screening method for identifying inhibitors of the expression of the hexose transporter genes by a positive phenotype
Yeast strain and screening method for identifying inhibitors of the expression of the hexose transporter genes by a positive phenotype
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机译:通过阳性表型鉴定己糖转运蛋白基因表达抑制剂的酵母菌株及筛选方法
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摘要
The present invention provides screening procedures for identifying inhibitors of components of regulatory networks by a positive phenotype and modified yeast cell lines suitable for said screening. The screening procedures are especially suited to screen for substances that re-sensitize resistant pathogenic microorganisms or tumor cells by suspending the expression of resistance-relevant genes. The invention further provides methods for constructing said cell lines and their use in screening systems.
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