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Method for enhancing the shelf life of donor blood by laser biostimulation

机译：通过激光生物刺激提高供体血液保存期限的方法

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摘要

A method for increasing the shelf life of donor blood contemplates the following steps. In the first step blood is transferred to a sterile container and mixed with an anticoagulant as indicated in step 20. The anticoagulant and donor blood are centrifuged in step 22 at about 4,000 rpm for about 15 minutes. After centrifuging the red blood cells are separated and placed in a sterile tube. In the next step the red blood cells are irradiated by a laser that emanates a wavelength of about 633 nm for a time period of about 24 hours. During rotation the RBCs are rotated to provide uniform exposure. Such laser biostimulation produces an enhancement of shelf life of donor blood by 66%.

机译：一种用于增加供血的保质期的方法包括以下步骤。第一步，将血液转移到无菌容器中，并按步骤 20 所示与抗凝剂混合。在步骤 22 中，将抗凝剂和供体血液以约4,000 rpm的速度离心约15分钟。离心后，分离红细胞并置于无菌管中。在下一步中，红细胞被发出约633 nm波长的激光照射约24小时。在旋转过程中，RBC旋转以提供均匀的曝光。这种激光生物刺激使供血的保存期限延长了66％。 展开▼

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公开/公告号US9011766B2

专利类型

公开/公告日2015-04-21

原文格式PDF

申请/专利权人 KING SAUD UNIVERSITY;
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申请/专利号US201213680199

发明设计人 VADIVEL MASILAMANI;MOHAMAD SALEH ALSALHI;AL-KHALID ISAM ZUHAIER;
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申请日2012-11-19

分类号A61L2/00;A61L9/00;B01J19/00;G01N23/00;A61N5/00;B01D61/00;A01N1/02;

国家 US

入库时间 2022-08-21 15:19:24

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3. METHOD FOR ENHANCING THE SHELF LIFE OF DONOR BLOOD BY LASER BIOSTIMULATION [P] . 美国专利： US2014140889A1 . 2014-05-22

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4. METHODS FOR EXTENDING THE SHELF-LIFE OF STORED DONOR BLOOD AND/OR RED BLOOD CELLS AND TREATED RED BLOOD CELL COMPOSITIONS PRODUCED THEREBY [P] . WO2021222074A1 . 2021-11-04

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5. METHOD FOR INCREASING STORAGE LIFE OF DONOR BLOOD [P] . 俄罗斯专利： RU94007466A . 1996-07-27

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9. 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Vascular304Mitophagy acts as a safeguard mechanism against human vascular smooth muscle cell apoptosis induced by atherogenic lipidsTranscriptional control and RNA species - Vascular307MicroRNA-34a role in vascular calcification308Local delivery of a miR-146a inhibitor utilizing a clinically applicable approach attenuates neointima formation after vascular injury309Long noncoding RNA landscape of hypoxic endothelial cells310Specific circulating microRNAs levels associate with hypertension, hyperglycemia and dysfunctional HDL in acute coronary syndrome patientsCytokines and cellular inflammation - Vascular313Phosphodiesterase5A up-regulation in vascular endothelium under pro-inflammatory conditions: a newly disclosed anti-inflammatory activity for the omega-3polyunsaturated aatty acid docosahexaenoic acid314Cardiovascular risk modifying with extra-low dose anticytokine drugs in rhematoid arthritis315Conversion of human M-CSF macrophages into foam cells reduces their proinflammatory responses to classical M1-polarizing activation316Lymphocytic myocarditis coincides with increased plaque inflammation and plaque hemorrhage in coronary arteries, facilitating myocardial infarction317Serum osteoprotegerin level predictsdeclined numerous of circulating endothelial- derived and mononuclear-derived progenitor cells in patients with metabolic syndromeGrowth factors and neurohormones - 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