Dihidropiridona P1 as factor XIa inhibitors

摘要

Pharmaceutical ingredients including these compounds and methods of treating hemoglobin and / or inflammation. 1. Characteristic requirement 1: a compound, whose characteristic is formula (1) or stereoisomer, a ceramic strength meter or a salt, and its medicament is acceptable, wherein: Ring A is independent of a set of formula (2);- - - - is an optional link; R¹ is independently selected from H, hydroxy and C₁₋₄ alkyl;R2,in each case, it is independently selected from H and hydroxyl; R⁴ is independently selected from H, OH, F, O-C₁₋₄ alkyl and CN; R⁸ᵃ is independently selected from H, F, Cl and Br; R⁸ᵇ is independently selected from H and F; and R⁸ᶜ is independently selected from H, F and CI.