Production of recombinant yeast host cell and method for the production of a product selected from the group consisting of 2,3 - butanediol, isobutanol, 2 - butanol, 1 - butanol, 2-butanone, valine, lysine, lactic acid, malic acid, alcohol, isoampilico and isoprenoides

摘要

Crabtree positive yeast cells that have endogenous expressed pyruvate decarboxylase genes inactivated and an engineered biosynthetic pathway utilizing pyruvate were found to have improved growth and product yield when glucose repression was reduced. These cells were able to grow in media containing a high glucose concentration.