Organometu00c1licos of palu00c1dio (II) complexes containing ligands benzodiazepu00cdnicos, method of obtaining and its effect as an anticonvulsant

摘要

Organometu00c1licos of palu00c1dio (II) complexes containing ligands benzodiazepu00cdnicos, method of obtaining and its effect as an anticonvulsant. This is an invention relating to the process of obtaining a potential metalofu00e0rmaco benzodiazepine on the basis of the palace, its incorporation in pharmaceutical formulations, and their use in the treatment of seizures.The results show that the tartamento acute with the complex du00edmu00e9rico bis [2 - {(7 - chlorine - 1 - meTill - 2 - oxo 2,3 dihydro - 1 - benzodiazepin - 5 - YL) phenyl - K ^ 2 ^ - C, n} - 109 ~ 2 ~ - acetatopalu00e1cio (II)], [diazpdoac] ~ 2 ~, derivative of diazepam, showed that the compound has anticonvulsant activity in models of neur Oquu00edmicos of seizure.Produced longer latency to seizure and protecting for the appearance of the same. The compound acts in the same receiver of diazepam, the GABA receptor ~ ~ - benzodiazepine.