Component for a lyophilized hiv or mass vaccine, liquid component or mass, pharmaceutical composition or vaccine, uses of the final component or mass or pharmaceutical composition and an antioxidant with at least one thiol functional group and methods of treating and reconstituting a lyophilized component, and kit

摘要

A component for a HIV vaccine comprising: a) an immunogenic fusion protein comprising Nef or an immunogenic fragment or derivative thereof, and p17 Gag and/or p24 Gag or immunogenic fragments or derivatives thereof, wherein when both p17 and p24 Gag are present there is at least one HIV antigen or immunogenic fragment between them, and b) a stabilising agent selected from the group comprising or consisting of monothioglycerol, cysteine, N-acetyl cysteine or mixtures thereof The invention also extends to HIV vaccines comprising the same and use in treatment/prevention of HIV.