Pharmaceutical composition for treating diseases associated with reduction in bone mass comprising ep4 agonist as active component

摘要

"PHARMACEUTICAL COMPOSITION FOR TREATMENT OF DISEASES ASSOCIATED WITH REDUCTION IN BONE MASS UNDERSTANDING AGONIST EP ~ 4 ~ AS ACTIVE COMPONENT". A pharmaceutical composition for topical administration for the prevention and / or treatment of diseases associated with reduction in bone mass comprising an EP-4-agonist as an active component. An EP-4-agonist comprising a compound having a prostaglandin structure as a representative having promoter action on bone formation so that it is useful in preventing and / or treating diseases associated with bone mass reduction ( bone diseases, such as primary osteoporosis, secondary osteoporosis, cancer bone metastasis, hypercalcemia, Paget's disease, bone loss and bone necrosis, postoperative osteogenesis, alterative bone graft therapy).