Substantially Pure compounds with defined Chemical formulas, Metabolites of Trans Clomiphene, Pharmaceutical Composition and Uses Thereof in the treatment of Secondary hypogonadism or a disorder associated with this male in a Human patient.

摘要

The present invention relates to substantially pure metabolites of irara-clomiphene. The invention is also directed to pharmaceutical compositions comprising these metabolites and their use in treating disorders including secondary hypogonadism, type 2 diabetes, elevated cholesterol, elevated triglycerides, wasting, lipodystrophy, female and male infertility, benign prostate hypertrophy, prostate cancer, breast cancer, ovarian cancer and endometrial cancer.