The Compound trans Clomiphene in Particulate form, with an average particle size of less than 30 microns, and at least 90 of the particles have a size of less than 50 microns; formulation which comprises, useful for the treatment of diabetes type 2 or secondary hypogonadism in male or pa Ra Treatment of Infertility and breast cancer in a woman, among other diseases.

摘要

The present invention provides iraws-clomiphene and pharmaceutically acceptable salts and solvates thereof, characterized in that trans-clomiphene is in particulate form having a specific size range. The invention is also directed to pharmaceutical compositions comprising or formulated using trans-clomiphene or pharmaceutically acceptable salts and solvates having a specified size range and their use in treating disorders including secondary hypogonadism, type 2 diabetes, elevated cholesterol, elevated triglycerides, wasting, lipodystrophy, female and male infertility, benign prostate hypertrophy, prostate cancer, breast cancer, ovarian cancer and endometrial cancer.