Non Aromatic substituted Heterocyclic Compounds; Pharmaceutical composition that includes a method for treating cancer; and selected glioma (glioblastoma), acute myelogenous leukemia, melanoma, non small cell lung cancer (NSCLC) cholangiocarcinomas and myelodysplastic syndromes (MDS), among others.

摘要

Provided are methods of treating a cancer characterized by the presence of a mutant allele of IDH1/2 comprising administering to a subject in need thereof a compound described here.