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Recombinant Antibodies with dual specificity for gangliosides GM3 and N - acetyl - glicolil GM3 and its use.
Recombinant Antibodies with dual specificity for gangliosides GM3 and N - acetyl - glicolil GM3 and its use.
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机译:对神经节苷脂GM3和N-乙酰基-glicolil GM3具有双重特异性的重组抗体及其用途。
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摘要
The present invention relates to new monoclonal antibodies and fragments of these antibodies, which have dual specificity and high affinity for N-acetyl GM3 and N-glycolyl GM3 and do not recognize other gangliosides. In another aspect, the present invention relates to the use of these antibodies and their fragments in the therapy of tumors characterized by a significant expression of any of the two antigens recognized by these antibodies, or a mixed expression of both antigens. Likewise, the invention relates to the use of these antibodies in the diagnosis of tumors expressing at least one of the two variants of the GM3 ganglioside.
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