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摘要

The present invention relates to a hybrid adenovirus-mediated gene expression vector characterized by at least the following, sir It is 3, 5 '.In particular: (i) Some of the first chains of the origin of alpha Delta e_uuuuuuuuuuuuuuuuuuuuu A sequence used to form a definite first alpha delta969959595kappa (four) cDNA, some from alpha lambda alpha chain.The sequence is a partially complementary RNA sequence consisting of at least one coding at least one of the alpha_gamma_. S gene partial sequence pi_lambda_alpha delta_lambda__ _ _ _ _ (V) and (VI) some second alpha delta_uuuuuuuuThe present invention relates to the best form of human body mediated by a hybrid adenovirus in a foreign gene of interest to others, including theta epsilon P alpha epsilon_kappa Regardless of the interleukin IL 12 gene in mammalian genes, a preference for human interleukin HLL - 12 is preferred.The invention also relates to the use of some methods to mix genetic material transfer operators in certain cells, especially tumor cells and some gentlemen. In some cells, the expression of AFP is preferred, as well as the use of an additional antigen to induce immune responses in foreign countries.