7-(1,2,4TRIAZOLO1,5-αPYRIDIN-6-YL)-4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDROISOQUINOLINE, PHARMACEUTICAL COMPOSITION BASED THEREON AND METHODS OF TREATING NEUROLOGICAL AND MENTAL DISORDERS

摘要

The present invention relates to novel [1,2,4]triazolo[1,5-α]pyridinyl-6-yl-substituted tetrahydroisoquinolines of formula (I); ;wherein the carbon atom designated * is in the R- or S-configuration; or a pharmaceutically acceptable salt or a solvate thereof and a pharmaceutical composition comprising a therapeutically effective amount of the compound of formula (I) or a salt or solvate thereof for the treatment of different neurological and mental disorders. The invention also relates to a method of treating a disorder which is created by or is dependent upon decreased availability of norepinephrine, dopamine, or serotonin, to methods of inhibiting synaptic norepinephrine, dopamine, or serotonin uptake in a patient, to a method of suppressing the desire of humans to smoke and to a method of suppressing the desire of humans to consume alcohol, comprising administering to a human in need a therapeutically effective amount of the compound of formula (I) or a salt or solvate thereof.