APPLICATION OF CAR, BASED ON ICOS, TO STRENGTHEN ANTI-TUMOR ACTIVITY AND LONG-TERM CAR SAVING

摘要

The present invention relates to compositions and methods for the treatment of malignant tumors in humans. The invention includes the introduction of genetically modified Th17 cells expressing CAR, containing an antigen-binding domain, a transmembrane domain, and an intracellular signaling domain of ICOS.