NEW WAYS AND INTERMEDIATE CONNECTIONS FOR OBTAINING (4bS, 5aR) -12-CYCLOGEXYL-N- (N, N-DIMETYLESULFAMOIL) -3-METHOXY-5A - ((1R, 5S) -3-METHI-3,8-DI-AI, -I-DI-AI-5A-5A-5A - (((1R, 5S) -3-METHYL) 3.2.1 OKTAN-8-CARBONIL) -4b, 5,5a, 6-TETRAHYDROBENZO 3,4 CYCLOPROP 5,6 AZEPINO 1,2-a INDOL-9-CARBOXAMIDE

摘要

Methods and intermediates for the preparation of (1aR, 12bS) -8-cyclohexyl-11-fluoro-N - ((1-methylcyclopropyl) sulfonyl) -1a - ((3-methyl-3,8-diazabicyclo [3.2.1] oct-8-yl) carbonyl) -1,1a, 2,12b-tetrahydrocycloprop [d] indolo [2,1-a] [2] benzazepine-5-carboxamide of the formula I, including pharmaceutically acceptable salts. The compound has activity against hepatitis C virus (HCV) and may be useful in treating people infected with HCV.