processes and intermediates for the preparation of (4bs, 5ar) -12-cyclohexyl-n- (n, n-dimethylsulfamoyl) -3-methoxy-5a - ((1r, 5s) -3-methyl-3,8- diazabicyclo 3.2.1 octane-8-carbonyl) -4b, 5,5a, 6-tetrahydrobenzo 3,4 cyclopropa 5,6 azepino 1,2-a indole-9-carboxamide

摘要

Patent and Methods of Preparation of (4bs, 5ar) -12-cyclohexyl-n- (n, n-dimethylsulfamoyl) -3-methoxy-5a - ((1r, 5s) -3- methyl-3,8-diazabicyclo [3.2.1] octane-8-carbonyl) -4b, 5,5a, 6-tetrahydrobenzo [3,4] cyclopropa [5,6] azepino [1,2-a] indole Carboxamide ". The present invention relates to methods and intermediates for the preparation of (1ar, 12bs) -8-cyclohexyl-11-fluoro-n - ((1-methylcyclopropyl) sulfonyl) -1a - ((3-methyl-3 , 8-diazabicyclo [3.2.1] oct-8-yl) carbonyl) -1,1a, 2,12b-tetrahydrocyclopropa [d] indolo [2,1-a] [2] benzazepine-5-carboxamide (formula i) including pharmaceutically acceptable salts. The compound has activity against the hepatitis c virus (hcv) and may be useful in treating those infected with hcv.