(4bS, 5aR) -12-cyclohexyl-N- (N, N-dimethylsulfamoyl) -3-methoxy-5a-((1R, 5S) -3-methyl-3,8-diazabicyclo 3.2. 1 Octane-8-carbonyl) -4b, 5,5a, 6-tetrahydrobenzo 3,4 cyclopropa 5,6 azepino 1,2-A indole-9-carboxamide Methods and intermediates

摘要

The present invention provides methods and intermediates for the preparation of (1a R , 12b S )-8-cyclohexyl-11-fluoro- N -((1-methylcyclopropyl)sulfonyl)-1a-((3-methyl-3,8-diazabicyclo[3.2.1]oct-8-yl)carbonyl)-1,1a,2,12b-tetrahydrocyclopropa[ d ]indolo[2,1- a ][2]benzazepine-5-carboxamide (formula I), including pharmaceutically acceptable salts. The compound has activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.