PRDM14 AND FAM19A4, MOLECULAR DIAGNOSTIC MARKERS FOR THE IDENTIFICATION OF HPV-INDUCED INVASIVE CANCER DISEASES AND PRIOR HIGH-DEGREE DAMAGE

摘要

The invention relates to a method for detecting HPV-induced pre-cancerous lesions of a high degree and HPV-induced invasive cancer, and this method includes determining the hypermethylation of the PRDM14 and / or FAM19A4 gene in cells, such hypermethylation indicates the presence of HPV-induced pre-cancerous lesions with invasive potential and HPV -induced invasive cancers. In addition, the invention includes the use of the PRDM14 gene and / or FAM19A4 in such a method and a test kit for determining the methylation of PRDM14 and / or FAM19A4.