NOVEL PIPERAZINE ANALOGS AS BROAD-SPECTRUM INFLUENZA ANTIVIRALS

摘要

A compound of Formula I is set forth, including pharmaceutically acceptable salts thereof: wherein Het is a 5 or 6-membered heterocycle with N, O, or S adjacent to the Ar substituent or adjacent to the point of attachment for the Ar substituent; Ar is aryl or heteroaryl; R is CH3, CH2F, or CHCH2; W is NO2, Cl, Br, CHO, CHCH2, or CN; X is Cl, CH3, or CN; Y is CH or N; and Z is C1-C6 alkyl, C3-C6 cycloalkyl, substituted aryl, substituted heteroaryl, OR1, or NHR1, wherein R1 is selected from the group of H, aryl, heteroaryl, C1-C6 alkyl and C3-C6 cycloalkyl. This compound is useful in compositions for the prevention and treatment of influenza virus.