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Diazepane-acetamide derivatives as selective 11ß-hsd1 inhibitors, method for their preparation and use thereof
Diazepane-acetamide derivatives as selective 11ß-hsd1 inhibitors, method for their preparation and use thereof
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机译:作为选择性11ß-hsd1抑制剂的二氮杂乙酰胺衍生物,其制备方法和用途
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摘要
The present invention relates to diazepane-acetamide derivatives of formula I as selective inhibitors of the enzyme 11-beta-hydroxysteroid dehydrogenase type 1 (11²-HSD-1) and the use of such compounds for the treatment and prevention of metabolic syndrome, diabetes, insulin resistance, obesity, lipid disorders, glaucoma, osteoporosis, cognitive disorders, anxiety, depression, immune disorders, hypertension and other diseases and conditions.
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